Postdoctoral Fellow Position investigating rRNA Modification

The Kothe group ( ) investigates how functional RNAs are generated in the cell. Specifically, we decipher the interplay of RNA modification with transcription, RNA folding, and RNA processing and how the integration of these processes enhances the functionality of RNAs for protein synthesis. Our research uncovers fundamental biological processes and identifies disease mechanisms and potential therapeutic targets.

We are looking for a postdoctoral fellow to study H/ACA snoRNPs that introduce pseudouridine modifications into ribosomal RNA (rRNA) during the early phases of ribosome synthesis. Additionally, H/ACA snoRNPs are involved in rRNA processing and folding. We want to gain deeper insight into these processes because ribosome synthesis is up-regulated in all cancers and dys-regulated in several inherited diseases including Dyskeratosis congenita.

The postdoctoral fellow will integrate biochemic...